Probing Life with Photons

Peer-Reviewed Publications

1. Jie Hui, Wonjoon Moon, Pu-Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, R. Rox Anderson, Jeremy Goverman, Jeffrey Gelfand, Seok-Hyun Yun, “Antimicrobial blue light-bathing therapy for wound infection control”, submitted, BioRxiv 589323 (2024).

2. Yubing Hu, Paolo Minzioni, Jie Hui, Ali K. Yetisen, Seok-Hyun Yun, “Fiber optic devices for diagnostics and therapy in photomedicine.” Advanced Optical Materials, in revision (2024).

3. Leopn G. Leanse, Carolina dos Anjos, Kylie Ryan Kaler, Jie Hui, Jeffrey M. Boyd, David C. Hooper, R. Rox Anderson, Tianhong Dai, “Blue light potentiates antibiotics in bacteria via parallel pathways of hydroxyl radical production and enhanced antibiotic uptake.” Advanced Science 10(33), 2303731 (2023).

4. Hao Yan, Sarah Forward, Kwon-Hyeon Kim, Yue Wu, Jie Hui, Anokhi Kashiparekh, Seok-Hyun Yun, “All-natural-molecule, bioluminescent photodynamic therapy results in complete tumor regression and prevents metastasis.” Biomaterials 296, 122079 (2023).

5. Pu-Ting Dong#, Yuewei Zhan#, Sebastian Jusuf#, Jie Hui#, Zeina Dagher, Michael Mansour, Ji-Xin Cheng, “Photoinactivation of catalase sensitizes Candida albicans and Candida auris to ROS-producing agents and immune cells.” Advanced Science 9(10), e2104384 (2022). [Link]

6. Pu-Ting Dong#, Sebastian Jusuf#, Jie Hui#, Yuewei Zhan, Yifan Zhu, George Liu, Ji-Xin Cheng, “Photoinactivation of catalase sensitizes wide-ranging bacteria to ROS-producing agents and immune cells.” JCI Insight 153079 (2022). [Link]

7. Pu-Ting Dong, Zeina Dagher, Jie Hui, Cheng Zong, Junjie Li, Yuewei Zhan, Meng Zhang, Michael K. Mansour, Ji-Xin Cheng, “Polarization-sensitive stimulated Raman scattering imaging resolves amphotericin B orientation in Candida membrane.” Science Advances 7(2) eabd5230 (2021). [Link]    Reported by [BU News]

8. Sebastian Jusuf, Pu-Ting Dong, Jie Hui, Erlinda R Ulloa, George Y Liu, Ji-Xin Cheng, “Granadaene photobleaching reduces the virulence and increases antimicrobial susceptibility of Streptococcus agalactiae” Photochemistry and Photobiology PMID: 33502005 (2021). [Link]

9. Jie Hui, Pu-Ting Dong, Lijia Liang, Taraknath Mandal, Junjie Li, Erlinda R. Ulloa, Yuewei Zhan, Sebastian Jusuf, Cheng Zong, Mohamed N. Seleem, George Y. Liu, Qiang Cui, Ji-Xin Cheng, “Photo-disassembly of membrane microdomains revives conventional antibiotics against MRSA.” Advanced Science 7(6), 1903117 (2020). [Link]    Reported by [BU News] [SPIE News] [Medical News Today] 

10. Sebastian Jusuf, Jie Hui, Pu-Ting Dong, Ji-Xin Cheng, “Synergistic eradication of methicillin-resistant Staphylococcus aureus by staphyloxanthin photolysis and low concentration silver nanoparticles. J. Phys. Chem. C 124(9), 5321-5330 (2020). [Link]

11. Jie Hui, and Ji-Xin Cheng, “Intravascular photoacoustic imaging of lipid-laden plaques: from fundamental concept towards clinical translation.” In Qifa Zhou & Zhongping Chen (Eds.), Multimodality Imaging – For Intravascular Application, Springer, ISBN 978-981-10-6306-0 (2020). [Link]

12. Pu-Ting Dong, Haroon Mohammad, Jie Hui, Junjie Li, Lijia Liang, Mohamed N. Seleem, and Ji-Xin Cheng, “Photolysis of staphyloxanthin in methicillin-resistant Staphylococcus aureus potentiates killing by reactive oxygen species.” Advanced Science 6(11), 1900030 (2019). [Link]    Reported by [BBC The Newsroom] [科普中国] [BU News] [Purdue News]

13. Ayeeshik Kole, Yingchun Cao, Jie Hui, Islam A. Bolad, Mouhamad Alloosh, Ji-Xin Cheng, and Michael Sturek, “Comparative quantification of arterial lipid by intravascular photoacoustic-ultrasound imaging and near-infrared spectroscopy-intravascular ultrasound.” J. Cardiovasc. Trans. Res. 1-10 (2018). [Link]

14. Yingchun Cao, Ayeeshik Kole, Jie Hui, Yi Zhang, Jieying Mai, Mouhamad Alloosh, Michael Sturek, and Ji-Xin Cheng, “Fast assessment of lipid content in arteries by in vivo intravascular photoacoustic tomography.” Scientific Reports 8(1), 2400 (2018). [Link]

15. Jie Hui, Yingchun Cao, Yi Zhang, Ayeeshik Kole, Pu Wang, Guangli Yu, Gregory Eakins, Michael Sturek, Weibiao Chen, and Ji-Xin Cheng, “Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque in human coronary artery at 16 frames per second.” Scientific Reports 7, 1417 (2017). [Link]

16. Yingchun Cao, Ayeeshik Kole, Lu Lan, Pu Wang, Jie Hui, Michael Sturek, and Ji-Xin Cheng, “Spectral assisted photoacoustic imaging for lipid composition differentiation.” Photoacoustics 7, 12-19 (2017). [Link]

17. Jie Hui, Rui Li, Evan Phillips, Craig J. Goergen, Michael Sturek, and Ji-Xin Cheng, “Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves.” Photoacoustics 4(1), 11-21 (2016). [Link]

18. Yingchun Cao#, Jie Hui#, Ayeeshik Kole, Pu Wang, Qianhuan Yu, Weibiao Chen, Michael Sturek, and Ji-Xin Cheng, “High-sensitivity intravascular photoacoustic imaging of lipid-laden plaque with a collinear catheter design.” Scientific Reports 6, 25236 (2016). [Link]    Reported by [OSA News] [Science Daily]

19. Jie Hui, Qianhuan Yu, Teng Ma, Pu Wang, Yingchun Cao, Rebecca S. Bruning, Yueqiao Qu, Zhongping Chen, Qifa Zhou, Michael Sturek, Ji-Xin Cheng, and Weibiao Chen, “High-speed intravascular photoacoutic imaging at 1.7 μm with a KTP-based OPO.” Biomed. Opt. Express 6(11), 4557-4566 (2015). [Link]

20. Jie Hui, and Ji-Xin Cheng, “Converting molecular vibration to mechanical wave for bond-selective imaging of deep tissue.” Chin. J. Chem. Phys. 28(4), 375-382 (2015). [Link]

21. Pu Wang, Teng Ma, Mikhail N. Slipchenko, Shanshan Liang, Jie Hui, K. Kirk Shung, Sukesh Roy, Michael Sturek, Qifa Zhou, Zhongping Chen, and Ji-Xin Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite Raman laser.” Scientific Reports 4, 06889 (2014). [Link]    Reported by [Purdue News]

Invited Talks/Seminars

1. Jie Hui, Seok-Hyun Andy Yun, Translational development of antimicrobial blue light for wound infection control: new therapeutic window, treatment regimen, and wearable device, 12822-28, invited talk, SPIE Translationa Research Forum, San Francisco, CA. Jan. 2024.

2. Jie Hui, Wonjoon Moon, Pu-Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, Rox Anderson, Jeremy Goverman, Jeff Gelfand, Seok-Hyun Yun, Translational development of antimicrobial blue light for wound infection control: new therapeutic window, treatment regimen, and wearable device, 12822-28, invited talk, SPIE Photonics West Conference, San Francisco, CA. Jan. 2024.

3. Jie Hui, Seok-Hyun Andy Yun, Endogenous chromophore-targeted antimicrobial phototherapy: from fundamental concept towards clinical application, invited talk by Marlan Scully, PQE2023, Snowbird, Utah (Jan. 2023).

4. Jie Hui, Seok-Hyun Andy Yun, Antimicrobial blue light-augmented wound therapy, MHSRS-22-05071, Military Health System Research Symposium, Kissimmee, FL. Sep. 2022 (invited talk at young investigator plenary session).

5. Jie Hui, Staphyloxanthin-targeting phototherapy platform to combat methicillin-resistant Staphylococcus aureus infections, Invited Zoom Seminar, University of Pavia, Italy, May 2022.

6. Jie Hui, Staphyloxanthin photolysis-mediated membrane disassembly as a new strategy to combat Staphylococcus aureus infection and antibiotic resistance, Wellman Center Research Seminar, Wellman Center for Photomedicine, Harvard Medical School, June 2020.

7. Jie Hui, Pu-Ting Dong, Lijia Liang, Taraknath Mandal, Junjie Li, Yuewei Zhan, Sebastian Jusuf, Cheng Zong, Qiang Cui, and Ji-Xin Cheng, “Inhibiting S. aureus antibiotic resistance via photo-disassembly of membrane microdomains.” 11223-29, invited talk, SPIE Photonics West Conference, San Francisco, CA. Feb. 2020.

8. Pu-Ting Dong, Zeina Dagher, Jie Hui, Yuewei Zhan, Michael K. Mansour, Ji-Xin Cheng, “Eradication of broad-spectrum multi-drug fungal pathogens through photoinactivation of a detoxifying enzyme.” 11223-29, SPIE Photonics West Conference, San Francisco, CA. Feb. 2020.

9. Jie Hui, Pu-Ting Dong, Ji-Xin Cheng, “Staphyloxanthin-targeting phototherapy platform for methicillin-resistant Staphylococcus aureus infections.” invited talk, Diabetic Lower Extremity Symposium, Boston, MA. Nov. 2019.

10. Jie Hui, Pu-Ting Dong, Junjie Li, Lijia Liang, Cheng Zong, and Ji-Xin Cheng, “Photo-disassembly of membrane microdomains revives a broad spectrum of antibiotics against MRSA persisters.” 10863-30, invited talk, SPIE Photonics West Conference, San Francisco, CA. Feb. 2019.

11. Pu-Ting Dong, Jie Hui, Junjie Li, Yifan Zhu, Lijia Liang, and Ji-Xin Cheng, “Eradication of broad-spectrum intracellular bacteria through photoinactivation of a detoxifying enzyme.” 10863-38, invited talk, SPIE Photonics West Conference, San Francisco, CA. Feb. 2019.

12. Jie Hui, “Intravascular photoacoustic imaging of lipid-laden plaque: technical development towards clinical translation”. Invited talk, Northeast Symposium on Biomedical Optics, Boston, MA. 2018.

13. Jie Hui, Pu-Ting Dong, Haroon Mohammad, Junjie Li, Lijia Liang, Mohamed N. Seleem, and Ji-Xin Cheng, Selective eradication of methicillin-resistant Staphylococcus aureus via photolysis of staphyloxanthin, MHSRS-18-1408, Military Health System Research Symposium, Kissimmee, FL. Aug. 2018 (invited talk at young investigator plenary session).

Conference Proceedings

1. Jie Hui, Pu-Ting Dong, Lijia Liang, Taraknath Mandal, Junjie Li, Erlinda R. Ulloa, Yuewei Zhan, Sebastian Jusuf, Cheng Zong, Mohamed N. Seleem, George Y. Liu, Qiang Cui, Ji-Xin Cheng, “Inhibiting Staphylococcus aureus antibiotic resistance via photo-disassembly of membrane microdomains.” Proc. SPIE 11223, 112230T (2020).

2. Pu-Ting Dong, Haroon Mohammad, Jie Hui, Xiaoyu Wang, Junjie Li, Lijia Liang, Mohamed N. Seleem, and Ji-Xin Cheng, “Staphyloxanthin photobleaching sensitizes methicillin-resistant Staphylococcus aureus to reactive oxygen species attack.” Proc. SPIE 10479, 104790R (2018).

3. Jie Hui, Yingchun Cao, Yi Zhang, Ayeeshik Kole, Pu Wang, Guangli Yu, Gregory Eakins, Michael Sturek, Weibiao Chen, and Ji-Xin Cheng. “Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque at speed of video-rate level.” Proc. SPIE 10064, 100640T (2017).

4. Yingchun Cao, Jie Hui, Ayeeshik Kole, Pu Wang, Weibiao Chen, Michael Sturek, and Ji-Xin Cheng, “Highly Sensitive Intravascular Photoacoustic Imaging with a Collinear Catheter Probe.” in Conference on Lasers and Electro-Optics, OSA Technical Digest, paper ATh4N.4 (2016).

5. Jie Hui, Rui Li, Pu Wang, Evan Phillips, Rebecca Bruning, Chien-Sheng Liao, Michael Sturek, Craig J. Goergen, and Ji-Xin Cheng. “Assessing carotid atherosclerosis by fiber-optic multispectral photoacoustic tomography.” Proc. SPIE 9323, 93233S (2015).

Patents

1. Method and device for annihilation of methicillin-resistant Staphylococcus aureus, Patent No. US11013933, granted 2021. 

2. Bactericidal methods and compositions, Patent No. US11110296, granted 2021. 

3. Photoacoustic catheter and imaging system using same, Patent No. US11109763, granted 2021. 

4. Bactericidal methods and compositions, Patent No. US11298563, granted in 2022. 

5. Bactericidal methods and compositions, Patent No. US11633622, granted in 2023. 

PhD Thesis

Jie Hui, Intravascular Photoacoustic Imaging of Lipid-Laden Plaque: From Fundamental Concept Towards Clinical Translation, Purdue University, Dec 2017.